^ Jump up to: a b c Devinsky, Orrin; Cilio, Maria Roberta; Cross, Helen; Fernandez-Ruiz, Javier; French, Jacqueline; Hill, Charlotte; Katz, Russell; Di Marzo, Vincenzo; Jutras-Aswad, Didier; Notcutt, William George; Martinez-Orgado, Jose; Robson, Philip J.; Rohrback, Brian G.; Thiele, Elizabeth; Whalley, Benjamin; Friedman, Daniel (22 May 2014). "Cannabidiol: Pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders". Epilepsia. 55 (6): 791–802. doi:10.1111/epi.12631. PMC 4707667. PMID 24854329.
In order to remove unwanted elements such as fats or waxes, CBD oil is subjected to a process called ‘Winterization’. Refined cannabidiol oil is stirred with alcohol and deep-frozen overnight.  A Butcher funnel or a piece of paper is then used to filter the fats out. Finally, the extracted oil is heated to the boiling point of alcohol so the alcohol evaporates.
As the benefits of CBD continue to become known, growers are modifying their crops to account for more cannabidiol and less tetrahydrocannabinol to create stronger medicinal plants. Some politicians believe that all plants with THC should be kept illegal, and as CBD plants become more commonly produced, doctors remind them that both compounds have certain benefits to be had by patients. The anti-nausea and appetite stimulating properties of THC make it an optimal treatment for some patients, depending upon their conditions and symptoms. Research also shows that the two compounds work best when together.
PureKana Natural CBD oil is an unflavored, dietary and nutritional supplement for increased health and vitality. It aims at relaxation and due to its compounds, it seems to have a relatively quick effect. All products go through laboratory testing to ensure safety and potency, and all of their CBD oils are regarded as being non-psychoactive. They also deliver to all 50 states which is a major bonus.
The equivalency factor is not designed to compare the effects of cannabis oil to dried cannabis, or provide dosage information. For many patients, consuming cannabis orally will produce much stronger effects than inhaling it. For example, when considering a product that has an equivalency factor of 12ml of oil to 1 gram of dried cannabis, and a patient who usually consumes 1 gram of dried product a day, this patient will likely use less than 12 ml of oil per day. Even for patients who have previous experience of using cannabis oil, it is recommend that you start with a low dose and go slow.

CBD vaporizer oils can be used in a vaporizer of your choice. They offer a healthy way of inhaling your daily dose of the CBD supplement. Vaping is a very direct way of ingesting CBD oil. When you vape, the CBD enters the lungs and goes directly into the bloodstream, completely bypassing the digestive system. This method allows for greater bioavailability.
Cannabis Sativa is the botanical name of the plant species. There are multiple strains of the Cannabis Sativa plant. One of the common strains is called Industrial Hemp and the other is Marijuana. These are different plants, but both come from the same family of plants. Industrial Hemp naturally produces higher levels of Cannabidiols (CBD) and low levels of tetrahydrocannabinol (THC). Industrial Hemp has been legalized for cultivating in the USA according to the Farm Bill Act. Marijuana plants are just the opposite producing high levels of THC and lower levels of CBD. The legal status of Marijuana varies vastly from state to state. At Zatural we use the Industrial Hemp strain for all of our Hemp Oil and CBD Oil products. All Zatural products are 3rd party tested to ensure there is no THC present. 
It was actually a bad bout of jet lag after a trip to California that inspired me to finally test out the CBD oil (I'll admit that my weed-based reservations kept me from trying it for the first few months). Knowing that the oil had also helped people with sleep issues, I squeezed one full dropper of the Everyday Plus oil onto my tongue, per the instructions, and waited.
Cannabidiol, or CBD, is one of at least 85 active cannabinoids identified within the Cannabis plant. It is a major phytocannabinoid, accounting for up to 40% of the Cannabis plant's extract, that binds to a wide variety of physiological targets of the endocannabinoid system within the body. Although the exact medical implications are currently being investigated, CBD has shown promise as a therapeutic and pharmaceutical drug target. In particular, CBD has shown promise as an analgesic, anticonvulsant, muscle relaxant, anxiolytic, antipsychotic and has shown neuroprotective, anti-inflammatory, and antioxidant activity, among other currently investigated uses [6, 5]. CBD's exact place within medical practice is still currently hotly debated, however as the body of evidence grows and legislation changes to reflect its wide-spread use, public and medical opinion have changed significantly with regards to its usefulness in a number of medical conditions ranging from anxiety to epilepsy.
An animal study using mice found repeated administration of CBD may help the hippocampus regenerate neurons, which could be useful for treating anxiety or depression. Research shows both SSRIs and CBD may promote neurogenesis. This is significant, because evidence suggests that severely impaired neuronal plasticity may influence suicidal behavior. Future research comparing CBD and SSRIs effect on neurogenesis could open up promising new avenues in how we understand depression and how to most effectively treat it.
The truth is, we still don’t have nearly the amount of research needed to fully understand the effects of each and every cannabinoid on our system. With that said, if you have symptoms or conditions that CBD can help with, go with pure CBD oil. If you are suffering from something more general like chronic pain, a full-spectrum hemp oil could bring some additional benefits from the extra cannabinoids. Try hemp-based products as well as pure CBD products, and let us know what you experience!

In order to create a system where oils can be provided to patients when the original prescription is expressed in grams of dried product, each Licensed Producer must provide an ‘Equivalency Factor’. This allows you to see how much oil you can purchase to be in line with your prescription and ensures that you do not go over your prescribed allowance. For example, a 60ml bottle of Blueberry Lamsbread Cannabis Oil, which has an equivalency factor of 12 ml of oil to 1 gram of dried cannabis, will use 5 grams of your possession limit.

Gleaned from the seeds of the hemp plant, hemp oil is a type of vegetable oil that you can use for cooking and preparing foods. It is a non-drug form of the hemp plant, unlike marijuana, which is also from the hemp plant. The oil is low in saturated fat and supplies certain nutrients. It also may have health benefits, making it worth adding to your healthy eating plan.

CBD oil contains CBD (and often other active compounds) in a carrier oil. There are a number of forms of CBD oil, including softgel capsules, tinctures, and under-the-tongue sprays. Some forms of CBD oil can also be applied directly to the skin, in the form of products like creams and salves. The concentration of CBD varies from product to product.

Despite this, it's important to know that inflammation is not inherently bad; in fact, it's a brilliant aspect of our immune system. When balanced, inflammation heals wounds and fights off infections. The problem with inflammation arises when it increases and never calms down. Like a forest fire burning on in perpetuity, people get hurt. Same goes with the fiery squall of insidious, chronic inflammation. As a natural anti-inflammatory, CBD can help quell the flame and fight chronic inflammation.

The case study notes that advanced chemotherapeutic agents had failed to control the blast counts (cells in the blood and bone marrow) in the patient and had devastating side effects that ultimately resulted in death. The cannabinoid therapy, on the other hand, had no toxic side effects and only psychosomatic properties, with an increase in the patient’s vitality.


First comes CBD, then comes the oil. Cannabidiol (CBD) is a cannabinoid, or chemical compound, found in both cannabis and hemp plants, explains Kimberly Cargile, the Executive Director of medical marijuana dispensary A Therapeutic Alternative. “There [are] hundreds of cannabinoids in the cannabis plant and hemp plants, and [CBD] is one of them,” she says.
And the final nail in industrial hemp’s proverbial coffin: Federal law in the United States prohibits the use of hemp leaves and flowers to make drug products. That said, isolating CBD nullifies these distinctions, rendering its source irrelevant as CBD isolate contains nothing but CBD. In this case, the differences between industrial hemp and whole-plant marijuana are far less significant.
And the final nail in industrial hemp’s proverbial coffin: Federal law in the United States prohibits the use of hemp leaves and flowers to make drug products. That said, isolating CBD nullifies these distinctions, rendering its source irrelevant as CBD isolate contains nothing but CBD. In this case, the differences between industrial hemp and whole-plant marijuana are far less significant.
This article may contain certain forward-looking statements and information, as defined within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934, and is subject to the Safe Harbor created by those sections. This material contains statements about expected future events and/or financial results that are forward-looking in nature and subject to risks and uncertainties. Such forward-looking statements by definition involve risks, uncertainties.

Receptra Naturals CBD products are derived from proprietary CBD rich hemp, grown on family owned and operated farms in Colorado using 100% organic farming practices on select organic soils without the use of pesticides or fungicides.  I got to know the folks at Receptra while dealing with Charlotte's Web Botanicals years back and continued to stay in contact when they left CW to form Receptra Naturals. 
The patient continued to use cannabis oil for 65 days. The family changed strains of the oil repeatedly, and some were more effective in increasing appetite and alleviating pain than others. The author of the case report suggests that cannabis oil needs to be explored further because there is potential that cannabinoids might show selectivity when attacking cancer cells, thereby reducing the widespread cytotoxic effects of conventional chemotherapeutic agents. Sadly, the young girl with ALL passed away due to gastrointestinal bleeding and a bowel perforation.
Hemp oil contains all of the essential amino acids, according to a 2000 article published in the "Journal of Nutraceuticals, Functional and Medicinal Foods." Essential amino acids help maintain the proteins in your body, which can prevent muscle loss. Hemp oil delivers small amounts of vitamins and minerals, including calcium, potassium, magnesium, copper, folate and vitamins B-6 and E.
It makes no sense to me that something that helps with anxiety has an irritability side effect – as a lot of my anxiety is co-mingled naturally with irritability. Further, I have noticed none of these side effects, given that if you become fatigued or sleepy, you adjust dose the next day. So I don’t call that a side effect – rather – an effect of taking too much.
A. The FDA has approved Epidiolex, which contains a purified drug substance cannabidiol, one of more than 80 active chemicals in marijuana, for the treatment of seizures associated with Lennox-Gastaut syndrome or Dravet syndrome in patients 2 years of age and older. That means the FDA has concluded that this particular drug product is safe and effective for its intended indication.

Despite this, it's important to know that inflammation is not inherently bad; in fact, it's a brilliant aspect of our immune system. When balanced, inflammation heals wounds and fights off infections. The problem with inflammation arises when it increases and never calms down. Like a forest fire burning on in perpetuity, people get hurt. Same goes with the fiery squall of insidious, chronic inflammation. As a natural anti-inflammatory, CBD can help quell the flame and fight chronic inflammation.


Cannabis sales have been illegal since the 1970 Controlled Substances Act was passed, with the only exceptions being the products made from the "mature stalk" and "sterilized seed" of the hemp plant, which could still be sold since they contained little to no psychoactive components. Even today, federal law has not changed its stance on cannabis. On the state level, however, things have changed dramatically. As of this writing, there are 30 states that have legalized the sale of cannabis in some form, whether that be medicinally or recreationally. Because federal law continues to outlaw the production and sales of cannabis aside from the CBD oil and hemp seed oil from hemp plants, it is illegal for states that have legalized cannabis to sell products across state borders.
Hemp oil — obtained by pressing benefit-rich hemp seeds — is slightly different than cannabis oil, although they both come from the same genus, Cannabis, and the same species, Cannabis Sativa. The term hemp is used to describe a Cannabis Sativa plant that contains only trace amounts of THC. Hemp is a high-growing plant that’s commonly grown for industrial uses, such as oils and topical ointments, as well as fiber for clothing, construction, paper and more.
Hippocampal neurogenesis: The hippocampus is a major brain area, and plays a critical role in a variety of brain functions. It’s most famous for its role in memory formation and cognition. Brain scans of patients suffering from depression or anxiety often show a smaller hippocampus, and successful treatment of depression is associated with the birth of new neurons (neurogenesis) in the hippocampus.

Despite this, it's important to know that inflammation is not inherently bad; in fact, it's a brilliant aspect of our immune system. When balanced, inflammation heals wounds and fights off infections. The problem with inflammation arises when it increases and never calms down. Like a forest fire burning on in perpetuity, people get hurt. Same goes with the fiery squall of insidious, chronic inflammation. As a natural anti-inflammatory, CBD can help quell the flame and fight chronic inflammation.


In terms of cancer, the suggestion is to have three doses of CBD oil each day, and gradually increase the amount to 1 gram per day. The full treatment is believed to take 90 days. Please note that CBD oil is still illegal in many countries, but there is a significant amount of research being done on its medical applications, and a number of reputable sources have put out guides regarding the use of CBD oil for treatment of many diseases.


While experts — including Cargile, Romanowski, and Carqueville — note that there hasn’t been a ton of research done on the potential risks of CBD oil, it’s thought to be a pretty low-risk product. “First of all, using anything topically reduces the risks right off the bat,” Cargile says. “There’s not a lot of research, however CBD and THC, cannabis and hemp have been used for thousands of years. And according to the Centers for Disease Control [and Prevention], which reports deaths in this nation, [marijuana] causes zero deaths every year so it’s found to be very safe.”
Tetrahydrocannabinol (THC) and cannabidiol (CBD) are two types of cannabinoids found naturally in the resin of the marijuana plant, both of which interact with the cannabinoid receptors that are found throughout the body. Although THC and CBD have been the most studied cannabinoids, there are many others identified to date including cannabinol (CBN), cannabigerol (CBG), Cannabidivarin (CBDV), and Tetrahydrocannabivarin (THCV) that can be found within the medical cannabis [10]. While both CBD and THC are used for medicinal purposes, they have different receptor activity, function, and physiological effects. If not provided in their activated form (such as through synthetic forms of THC like Dronabinol or Nabilone), THC and CBD are obtained through conversion from their precursors, tetrahydrocannabinolic acid-A (THCA-A) and cannabidiolic acid (CBDA), through decarboxylation reactions. This can be achieved through heating, smoking, vaporization, or baking of dried unfertilized female cannabis flowers.
Collin, C., Ehler, E., Waberzinek, G., Alsindi, Z., Davies, P., Powell, K., Notcutt, W., O'Leary, C., Ratcliffe, S., Novakova, I., Zapletalova, O., Pikova, J., and Ambler, Z. A double-blind, randomized, placebo-controlled, parallel-group study of Sativex, in subjects with symptoms of spasticity due to multiple sclerosis. Neurol.Res. 2010;32(5):451-459. View abstract.
Check Dr. Stephen Porges’ work, as well as Stanley Rosenburg. Both treat trauma and the vagus nerve’s role in bodily symptoms, which cause a lot of the symptoms you mention, as well as other people here. Some of Stanley Rosenburg’s simple exercises along with Stephen Porges’ work, can realign the vagus nerve and when done regularly have a cumulative effect. Basically, most symptoms, even seizures can be caused by misalignments and/or contracted muscles, (even the tiniest muscle in the human body, the stapedius muscle when chronically contracted can cause havoc on body) all under the umbrella of the vagus nerve (polyvagal nervous system). This is very well researched and is cutting edge treatment without the use of drugs of any kind. Some of Porges’ treatments use music, believe it or not, specially designed headsets with bone conduction. But please research, there are therapists trained in this field and in meantime, you can self-apply Stanley Rosenburg’s Basic Exercise, as well as others, first and you will see drastic results.
PTSD. My husband suffers chronic PTSD from active military service. We live not far from a large Army base and though my husband served with another counties military we hear stories constantly of family breakdowns over PTSD. It’s not a easy path but I’m hoping one day to find something to stop the endless trips to the psych ward. It’s just not right that those who serve come home to no government help.

Dosage is important, because CBD can have side effects—the most common are tiredness, diarrhea, and changes in appetite and weight—so it’s best not to take more than you need. As CBD becomes more prevalent, says J. Michael Bostwick, M.D., a psychiatrist at Mayo Clinic in Rochester, MN, “I’m reasonably certain new kinds of side effects will emerge.”

Many a time, multiple cannabinoid compounds are used together, either knowingly or unknowingly.  It is, hence, tough to discern the extent to which each compound is involved in causing the desired effect. There are cases where a group of cannabinoids works synergistically in bringing about bodily reactions. Studies selectively employing CBD oil are few in number, but promising.
According to the National Eczema Association, “Cannabinoids represent an exciting prospect for the future of AD therapy. With measurable anti-itch, anti-pain, anti-microbial and anti-inflammatory properties, the effect of cannabinoids in patients with AD has already begun to be demonstrated.” (10) Cannabinoids can be found in both cannabis oil and CBD oil.
REM behavior disorder: REM behavior disorder (RBD) is a parasomnia disorder characterized by shouting, becoming physically agitated, or otherwise acting out during sleep. For many, RBD is a symptom of a larger, more serious condition or disorder, such as Alzheimer’s disease or PTSD. CBD oil minimizes the symptoms of RBD, and also alleviates the anxiety and painful symptoms that often accompany disorders that lead to RBD.
I started using hemp oil a week ago…i baked some bite sized pasties today for daily dosea…i put 2 cap fills in my bath also. EVERYTHING HAS CHANGED… my depression is lifting my appetite has lessened I don’t want to sleep all day my sight clearer, skin smoother and face looks less aged. My pain has subsided substantially…i feel like a new person. I am in aww of this amazing life changing product I bought a 32 oz bottle and I use it for everything. Oh ya and my digestion is in way better condition…

Full Spectrum CBD Oil contains some of the same terpenes as dried cannabis bud. Terpenes are the aroma molecules found in plants. Beta-caryophyllene (pepper) and myrcene (musk) are both been found in hemp oil.  According to recent research, beta-caryophyllene acts as a cannabinoid in the body. It engages some of the same cell sites as smoked cannabis. In particular, the terpene interacts with cell receptors that regulate the immune system.  Myrcene has been found to have antidepressant and anti-inflammatory effects. It also acts as an antioxidant and helps molecules move across cell membranes. The combination of essential fatty acids, vitamins, antioxidants and healing terpenes make hemp oil one powerful superfood.

The ECS is responsible for setting the baseline activity levels of our immune system and nervous system, which then work to maintain our health. When the ECS falls out of whack, the systems that are regulated by it can begin to malfunction. CBD promotes the normal health and function of the endocannabinoid system, so it’s possible that CBD can help to alleviate the symptoms of conditions that are caused by dysfunction of the endocannabinoid system.
Our premium hemp oil drops has the listed amount of full spectrum hemp oil listed on the front of the bottle in milligrams. We offer three different strengths. Our base strengths at 300mg to 600mg, then our 3x strength products 1,000mg to 2,000mg, and last our 5x strength which is our strongest product at 1,500mg to 3,000mg. Here is a link to the product.
Thank you for reaching out to us. You could most definitely try our premium hemp oil drops or soft gels. Our premium hemp oil products are great for assisting with a lot of different things such as pain, inflammation, stress, anxiety, mood and sleep. I would start out with our 3x strength option that we have available, and the best method is the drops. You take the recommended amount of drops listed on the bottle, under your tongue. You let the drops sit there for 30 seconds. After the 30 seconds, you swallow the remaining oil in your mouth. Buy doing so this will enter your bloodstream to deliver faster results. Although, I would recommend talking to a doctor before going off any prescribed medicine.

CBD oil is made by mixing the extracted CBD or cannabidiol from the cannabis or marijuana plant (Cannabis Sativa) with coconut or hemp seed oil. CBD oil possesses cannabidiol; while THC is psychoactive, CBD is not, thereby helping relieve pain, treating anxiety and depression, fighting cancer, reducing anxiety. It also improves the quality of sleep, boosts appetite, and optimizes digestion.
Marijuana can produce acute psychotic episodes at high doses, and several studies have linked marijuana use to increased risk for chronic psychosis in individuals with specific genetic risk factors. Research suggests that these effects are mediated by THC, and it has been suggested that CBD may mitigate these effects.xxxi There have been a few small-scale clinical trials in which patients with psychotic symptoms were treated with CBD, including case reports of patients with schizophrenia that reported conflicting results; a small case study in patients with Parkinson’s disease with psychosis, which reported positive results; and one small randomized clinical trial reporting clinical improvement in patients with schizophrenia treated with CBD.xxxii Large randomized clinical trials would be needed to fully evaluate the therapeutic potential of CBD for patients with schizophrenia and other forms of psychosis.

CBD Oil

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