^ Jump up to: a b c d Campos AC, Moreira FA, Gomes FV, Del Bel EA, Guimarães FS (December 2012). "Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders". Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences (Review). 367 (1607): 3364–78. doi:10.1098/rstb.2011.0389. PMC 3481531. PMID 23108553.
Green Roads World isn’t your standard cut-&-dry CBD reseller. They actually custom the oil to help treat your medical condition. Green Roads World employees a team of physicians, chemists and other health care professionals to provide affordable and reliable medications that are dosed to perfection for each patient. Green Roads has been voted on numerous Top 5 CBD lists due to their high quality products. They have truly done amazing things with their process of removing lipids and fats to create a 99% pure CBD crystal.
NIDA is currently collaborating with the National Institute on Neurological Disorders and Stroke to evaluate CBD in animal models of epilepsy in order to understand the underlying mechanisms and optimize the conditions under which CBD may treat seizure disorders, and determine whether it works synergistically with other anti-seizure medications. In addition, clinical trials are currently underway by GW Pharmaceuticals, testing the efficacy of Epidiolex, a purified CBD extract, for treatment of pediatric epilepsy.
I first encountered CBD while on sabbatical a few years back. As I drove up the Oregon Coast Highway, it was hard to miss all the cannabis shops along the Pacific. I stopped in one, perused the menu, and selected two marijuana specials — Nine-Pound Hammer and Trainwreck — and some CBD gummy bears. The cannabis was, well, as advertised, and the CBD candy, as far as I could tell, was a fruit-flavored placebo.
CBD has shown therapeutic efficacy in a range of animal models of anxiety and stress, reducing both behavioral and physiological (e.g., heart rate) measures of stress and anxiety.xxxiii,xxxiv In addition, CBD has shown efficacy in small human laboratory and clinical trials. CBD reduced anxiety in patients with social anxiety subjected to a stressful public speaking task.xxxv In a laboratory protocol designed to model post-traumatic stress disorders, CBD improved “consolidation of extinction learning”, in other words, forgetting of traumatic memories.xxxvi The anxiety-reducing effects of CBD appear to be mediated by alterations in serotonin receptor 1a signaling, although the precise mechanism remains to be elucidated and more research is needed.xxxvii
Dispensaries: In states where marijuana is legal for recreational use, dispensaries are a common sight. They are much rarer in states with more restrictions. In states that permit the use of medical marijuana, hemp-based CBD oils do not normally require a prescription but marijuana-based oils do. Like brick-and-mortar locations, dispensaries offer more customer service. However, as noted, this may not be an option depending on the buyer’s state of residence. Also, CBD oil prices tend to be significantly higher at dispensaries.
Cannabidiol can cause sleepiness or drowsiness. Using it along with other herbs and supplements that have the same effect might cause too much sleepiness. Some of these herbs and supplements include calamus, California poppy, catnip, hops, Jamaican dogwood, kava, L-tryptophan, melatonin, sage, SAMe, St. John's wort, sassafras, skullcap, and others.
Receptra Naturals CBD products are derived from proprietary CBD rich hemp, grown on family owned and operated farms in Colorado using 100% organic farming practices on select organic soils without the use of pesticides or fungicides. I got to know the folks at Receptra while dealing with Charlotte's Web Botanicals years back and continued to stay in contact when they left CW to form Receptra Naturals.
Although the exact mechanism and magnitude of effects of THC and CBD are not fully understood, CBD has been shown to have analgesic, anticonvulsant, muscle relaxant, anxiolytic, neuroprotective, anti-oxidant, and anti-psychotic activity. This wide variety of effects is likely due to it's complex pharmacological mechanisms. In addition to binding to CB1 and CB2 receptors of the endocannabinoid system, there is evidence that CBD activates 5-HT1A serotonergic and TRPV1–2 vanilloid receptors, antagonizes alpha-1 adrenergic and µ-opioid receptors, inhibits synaptosomal uptake of noradrenaline, dopamine, serotonin and gaminobutyric acid and cellular uptake of anandamide, acts on mitochondria Ca2 stores, blocks low-voltage-activated (T-type) Ca2 channels, stimulates activity of the inhibitory glycine-receptor, and inhibits activity of fatty amide hydrolase (FAAH) [1, 2].
Thoughts: I liked the lavender flavor more than I thought I would, but I've tried SelectCBD in the past, so I wasn't too shocked. The brand's peppermint CBD oil is my go-to morning oil, and lemon ginger is great for a subtle flavor, but the lavender overwhelmed my senses (in a good way?) and left me feeling very zen. I could see this being perfect in a mug of tea or just before bed.
According to the National Eczema Association, “Cannabinoids represent an exciting prospect for the future of AD therapy. With measurable anti-itch, anti-pain, anti-microbial and anti-inflammatory properties, the effect of cannabinoids in patients with AD has already begun to be demonstrated.” (10) Cannabinoids can be found in both cannabis oil and CBD oil.
Unfortunately due to the disappointing and down right inaccurate position of the federal government in classifying Cannabis as a schedule one drug, most research institutions risk federal funding if they conduct real research on Cannabis. This has dramatically limited the potential for real research by real scientists to be conducted. That research is critical to better understanding the multitude of therapeutic effects of the various chemical constituents found in Cannabis.
In 2017, the National Academies of Sciences, Engineering and Medicine convened a panel of experts to review the health effects of cannabis and cannabinoids. They examined more than 10,000 studies, most of which examined marijuana, not CBD. They found evidence that some cannabinoids — not including CBD — are effective for pain, nausea from chemotherapy and muscle spasms in multiple sclerosis.
Phytocannabinoids are the herbal, natural and classical cannabinoids found in the cannabis plant. The glandular structure called the trichomes is where the concentrated viscous resin of the plant is found. There are over 60 cannabinoids that have been isolated from the plant. Tetrahydracannabinol (THC), Cannabidiol (CBD) and Cannabinol (CBN) are the most prevalent ones and have also been the most studied. Cannabidiol (CBD) accounts for up to 40% of the plant’s extract. It has been widely reported that CBD offers the greatest possible benefits of any of the extracts found in the plant. CBD can also be derived from hemp. Hemp and cannabis both contain large amounts of natural CBD, but hemp is naturally low in THC; thus, making it easier for manufacturers to create high CBD-infused products with low to non-existent THC levels. Since THC is (mostly) still illegal in the United States, most CBD items we carry are derived from hemp. Each CBD product varies in the amount of CBD and THC levels found in the product. No items we carry are over the legal limit of THC levels, which is 0.3%, according to U.S. Federal Law.
Although CBD oils aren’t regulated by the FDA, purchasing products stateside from one of the nine states where recreational and medical cannabis use is legal will likely result in a higher-quality product than buying one made with hemp-derived CBD oil imported from abroad, says Martin Lee, director of Project CBD, a nonprofit that promotes medical research into CBD.
A review published in 2017 in the journal Frontiers in Pharmacology described how CBD may work to protect the hippocampus — the part of the brain responsible for several important functions, such as learning, memory and navigation — during times of stress, and may also help prevent brain-cell destruction that results from schizophrenia. Another 2017 review published in the journal Annals of Palliative Medicine summarized a handful of studies that suggest cannabis oils containing THC or CBD, or both, may help with chronic pain management, but the mechanism is unclear.
Although both oils are generally safe for use, the main difference between hemp oil and marijuana oil comes down to the THC content, which contributes to their different side effects. Marijuana’s THC content naturally contributes to more potential side effects related to memory, learning, and general cognition, which invariably means you shouldn’t be doing anything important, operating heavy machinery, or driving after taking marijuana oil. By comparison, hemp oil has far fewer side effects. Most side effects are related to hemp oil’s high polyunsaturated fat content, which may contribute to heart disease and digestive problems, but only if you are ignoring serving recommendations.
Now 13, Jackson — whose diagnosis is undetermined — continues to use marijuana every day. (Like many patients, he ingests it in droplet form, which allows for more precise dosing and avoids lung problems.) He still has seizures, but they are less severe and they occur once every week or two, down from around 200 a month before he started using cannabis. He is back in school full time and is well enough to go on hikes and bike rides with his family.
Iannotti FA, Hill CL, Leo A, Alhusaini A, Soubrane C, Mazzarella E, Russo E, Whalley BJ, Di Marzo V, Stephens GJ: Nonpsychotropic plant cannabinoids, cannabidivarin (CBDV) and cannabidiol (CBD), activate and desensitize transient receptor potential vanilloid 1 (TRPV1) channels in vitro: potential for the treatment of neuronal hyperexcitability. ACS Chem Neurosci. 2014 Nov 19;5(11):1131-41. doi: 10.1021/cn5000524. Epub 2014 Jul 29. [PubMed:25029033]
CBD is short for cannabidiol, a cannabinoid compound that is found in hemp and marijuana. Both hemp and marijuana are part of the plant family known as Cannabis. The main difference between marijuana and hemp is the level of THC in each. THC, like CBD, is a cannabinoid compound. There are 60 different known cannabinoids, but THC is the most well-known—the Beyoncé of cannabinoids, if you will. The reason THC is so famous is because it's associated with the psychoactive high that people experience after smoking or ingesting weed.