THC and CBD are metabolized in the liver by a number of cytochrome P450 isoenzymes, including CYP2C9, CYP2C19, CYP2D6 and CYP3A4. They may be stored for as long as four weeks in the fatty tissues from which they are slowly released at sub-therapeutic levels back into the blood stream and metabolized via the renal and biliary systems. The main primary metabolite of CBD is 7-hydroxy-cannabidiol.
1 Active Not Recruiting Treatment Fumarate Hydratase (FH)-Deficient Tumors / Lung Cancer Non-Small Cell Cancer (NSCLC) / Mesothelioma / Renal Cell Adenocarcinoma / Succinate Dehydrogenase (SDH)-Deficient Gastrointestinal Stromal Tumors (GIST) / Succinate Dehydrogenase (SDH)-Deficient Non-gastrointestinal Stromal Tumors / Triple-Negative Breast Cancer (TNBC) / Tumors Harboring Amplifications in the cMyc Gene / Tumors Harboring Isocitrate Dehydrogenase-1 (IDH1) and IDH2 Mutations / Tumors, Solid 1
NuLeaf Naturals is headquartered in Colorado, but we ship anywhere in the US. All of our organic CBD oil products will be sent to you via USPS, FedEx, or UPS and should arrive in just 2-3 business days. We offer special pricing options for bulk orders. If you sell health and wellness products and would be interested in promoting medical cannabis oil, consider becoming a wholesale CBD oil partner with us.

Even though marijuana is listed as a dangerous drug, there have been no direct fatalities recorded. The overdose levels are far too high for anyone to ingest. In fact, the overdose levels are 1000 times higher than the effective dose of 15 mg. Any fatalities connected to marijuana have been due to driving while under the influence of THC, trouble with the law because of possession, or smoking weed during a pregnancy (infant fatality).


^ "Fats and fatty acids contents per 100 g (click for "more details") example: avocado oil; user can search for other oils". Nutritiondata.com, Conde Nast for the USDA National Nutrient Database, Standard Release 21. 2014. Retrieved 7 September 2017. Values from Nutritiondata.com (SR 21) may need to be reconciled with most recent release from the USDA SR 28 as of Sept 2017.

In recent years, CBD has generated a tremendous amount of interest among consumers, clinicians, and scientists. Why? Not only does evidence suggest CBD counteracts many of THC’s adverse effects, but numerous animal studies and accumulating evidence from human experimental, clinical, and epidemiological studies suggest CBD has powerful anti-anxiety properties. Administered acutely (“as needed”), it appears safe, well-tolerated, and may be beneficial to treat a number of anxiety-related disorders, including:

WELLGRADE EST. 2017 is exclusively selected hemp oil, made with ‘the feel good plant’ and containing the unique combination of essential fatty acids which have a positive impact on your health in and out. Our product is manufactured in the USA from certified Colorado Hemp, thoroughly tested, CA in a FDA registered facility for quality and consistency. Wonderful product that work wonders!

Yet even those who believe in this power recognize that CBD medicine remains largely unexplored: Treatments are not systematized, many products are not standardized or tested, and patients (or their parents) are generally left to figure out dosing on their own. While some suppliers and dispensaries test the CBD and THC levels of their products, many do not. “We really need more research, and more evidence,” Kogan says. “This has to be done scientifically.”
While the science behind CBD oil assuaged many of my concerns, Charlotte Figi's inspiring story was the kicker. Figi, a 6-year-old girl diagnosed with a rare and resistant form of epilepsy known as Dravet syndrome, was actually placed on hospice care and given a "do not resuscitate" order when her parents, desperate and frustrated with pharmaceutical medication, considered medical marijuana. Charlotte is now 99% seizure-free since she began supplementing with Charlotte Web's CBD oil, which the brand named after Figi. 

Cannabidiol (CBD) is a naturally occurring compound found in the resinous flower of cannabis, a plant with a rich history as a medicine going back thousands of years. Today the therapeutic properties of CBD are being tested and confirmed by scientists and doctors around the world. A safe, non-addictive substance, CBD is one of more than a hundred “phytocannabinoids,” which are unique to cannabis and endow the plant with its robust therapeutic profile.


Hemp oil is also rich in "super" polyunsaturated fatty acids, most notably gamma-linolenic acid and stearidonic acid. Although these are not essential fatty acids, they may help reduce the symptoms of atopic dermatitis and other skin conditions. However, the amount of these non-essential fatty acids varies according to the quality of the hemp plant the acids were derived from.

Like Elixinol, CBD Essence has been around for quite a few years and they definitely know a thing or two about hemp oil. The owner Don has actually been around the pharmaceutical industry for some years, and therefore knows how to deliver a quality and effective product. All of their oils are created using CO2 extraction methods, which have been known to be safer and more effective than solvent-based extraction. They avoid CBD isolates, and they always disclose lab test results to ensure there are no heavy metals or contaminants in the oil.


In 2014, President Obama signed the Farm Bill of 2014 into law. This law contained a section that removed hemp from Schedule 1 of the Controlled Substances Act. It also created a legal structure that made cultivation and research of hemp legal in states that wanted to initiate “Pilot Research Programs” into the cultivation and marketing of hemp and hemp-derived products.
These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not meant to diagnose, treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition.
Infusions: Research and opportunity have driven chefs and chemists to infuse CBD into all sorts of readily usable products, such as edibles to elixirs, sublingual sprays, capsules and even topicals. Much like concentrates, each infusion sports specific combinations or isolations of CBD, THC, and other cannabinoids, allowing users to pick and choose products that suit their exact needs. CBD topicals, for example, are incredibly effective when applied to surface-level problems like bruises, joint aches, and headaches, and have been scientifically proven to successfully combat skin-based issues including pruritus with far broader implications.

Hemp oil is a great source of high-quality nutrients and has a long history of use in Eastern culture as a multi-purpose natural remedy. Despite its widespread popularity, prejudice related to its association with Marijuana it has kept it from common use in the West. While Hemp oil contains virtually no THC (the psychoactive element in cannabis) hemp oil is still concerning to some. Thankfully, education is prevailing and the market for hemp oil is growing in the United States, with an increasing number of people seeking it out for its reported health benefits.


Hemp and Marijuana come form the same plant family, but are completely different in function, cultivation and application. Marijuana generally has a high level of THC (a psychoactive compound that makes you feel “high”) and is used for medicinal or recreational purpose. Hemp contains a negligible amount of THC (but is high in CBD) and is used in dietary supplements, skin products, clothing and paper.

You can use Nutiva Organic Hempseed Oil in smoothies, salads, vegetables and pasta dishes. To conserve the essential fatty acids, we suggest you use it raw or gently heated. It's not suitable for frying. Hemp is loaded with all 20 amino acids, including the nine essential amino acids that are not manufactured in the body, and must come from food. Amino acids are essential for many metabolic processes, including building muscle tissue.

Hemp Oil

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