In general, the human body has specific sites that are allotted to cannabinoids, called the cannabinoid receptor sites. Receptors are mechanisms to which the cannabinoids naturally present in the human body as well as the ones artificially ingested/ applied attach themselves. There are two kinds of receptors for cannabinoids, the CB1, and the CB2. While the CB1 receptors are present in the brain, the CB2 receptors can be found in the immune system.
When I first learned about CBD oil, I'll admit I was a bit skeptical. My mind immediately turned to weed and the unnerving experiences I'd had with heightened anxiety in college. For me, a person who's already predisposed to overthinking, marijuana, no matter what the form, would typically put my mind into overdrive and result in a common yet dreaded side effect: paranoia.
^ Jump up to: a b c d Boggs, Douglas L; Nguyen, Jacques D; Morgenson, Daralyn; Taffe, Michael A; Ranganathan, Mohini (6 September 2017). "Clinical and preclinical evidence for functional interactions of cannabidiol and Δ9-tetrahydrocannabinol". Neuropsychopharmacology. 43 (1): 142–154. doi:10.1038/npp.2017.209. ISSN 0893-133X. PMC 5719112. PMID 28875990.
Hemp Oil is most commonly sourced from the Cannabis Sativa (Industrial Hemp) plant seed. It is also called Hemp Seed Oil. Hemp Oil is regulated in its production and is tested for THC and CBD levels, however it does not contain either of those Cannabinoids. Test have shown that there are no cannabinoids present in the seeds of the hemp plant. Hemp Oil is most commonly referred to as a Superfood, because of the high levels of Omegas, Vitamins, and other Nutrients. It may also assist with Pain, and stress due to its naturally occurring nutrients. Hemp Oil is also excellent for Hair and skin thanks to all of those Omegas and Vitamins!
In addition to the well-known activity on CB1 and CB2 receptors, there is further evidence that CBD also activates 5-HT1A/2A/3A serotonergic and TRPV1–2 vanilloid receptors, antagonizes alpha-1 adrenergic and µ-opioid receptors, inhibits synaptosomal uptake of noradrenaline, dopamine, serotonin and gamma-aminobutyric acid (GABA), and cellular uptake of anandamide, acts on mitochondria Ca2+ stores, blocks low-voltage-activated (T-type) Ca2+ channels, stimulates activity of the inhibitory glycine-receptor, and inhibits activity of fatty amide hydrolase (FAAH) [1, 2].
Under federal law, cannabis (from which both CBD and marijuana are derived) is illegal everywhere, although the laws against it aren’t generally enforced in states that have legalized marijuana. Some manufacturers claim that CBD culled from legally imported industrial hemp, which has little to no THC, is fine to ship across the U.S., but many experts disagree, noting that because hemp comes from the same species as marijuana, cannabis sativa, all CBD falls under the DEA’s Schedule 1 designation. “This creative interpretation of the law runs afoul of reality,” says the Brookings Institution, a Washington, DC, think tank.
That leaves those touting CBD’s effectiveness pointing primarily to research in mice and petri dishes. There, CBD (sometimes combined with small amounts of THC) has shown promise for helping pain, neurological conditions like anxiety and PTSD, and the immune system—and therefore potentially arthritis, diabetes, multiple sclerosis, cancer, and more.
Inhaling cannabis may involve minor issues due to the combustion process, while using cannabis oil does not result in the same effects since it does not require being heated. Since its benefits can be enjoyed without smoking, the remedy is often considered for children with severe health conditions, like epilepsy. Smokers may want to consider a vaporizer for whole-plant cannabis consumption.
To date, 23 states and the District of Columbia have passed laws allowing marijuana to be used for a variety of medical conditions. Fifteen additional states have enacted laws intended to allow access to CBD oil and/or high-CBD strains of marijuana. Interest in the potential therapeutic effects of CBD has been growing rapidly, partially in response to media attention surrounding the use of CBD oil in young children with intractable seizure disorders including Dravet syndrome and Lennox-Gastaut syndrome. While there are promising preliminary data, the scientific literature is currently insufficient to either prove or disprove the efficacy and safety of CBD in patients with epilepsy.i and further clinical evaluation is warranted. In addition to epilepsy, the therapeutic potential of CBD is currently being explored for a number of indications including anxiety disorders, substance use disorders, schizophrenia, cancer, pain, inflammatory diseases and others. My testimony will provide an overview of what the science tells us about the therapeutic potential of CBD and of the ongoing research supported by NIH in this area.
Cannabidiol, or CBD, is one of at least 85 active cannabinoids identified within the Cannabis plant. It is a major phytocannabinoid, accounting for up to 40% of the Cannabis plant's extract, that binds to a wide variety of physiological targets of the endocannabinoid system within the body. Although the exact medical implications are currently being investigated, CBD has shown promise as a therapeutic and pharmaceutical drug target. In particular, CBD has shown promise as an analgesic, anticonvulsant, muscle relaxant, anxiolytic, antipsychotic and has shown neuroprotective, anti-inflammatory, and antioxidant activity, among other currently investigated uses [6, 5]. CBD's exact place within medical practice is still currently hotly debated, however as the body of evidence grows and legislation changes to reflect its wide-spread use, public and medical opinion have changed significantly with regards to its usefulness in a number of medical conditions ranging from anxiety to epilepsy.
REM behavior disorder: REM behavior disorder (RBD) is a parasomnia disorder characterized by shouting, becoming physically agitated, or otherwise acting out during sleep. For many, RBD is a symptom of a larger, more serious condition or disorder, such as Alzheimer’s disease or PTSD. CBD oil minimizes the symptoms of RBD, and also alleviates the anxiety and painful symptoms that often accompany disorders that lead to RBD.
Individuals are continuously suffering varying degrees of anxiety about death. We did a study on “An overview of Death Anxiety”, https://goo.gl/PvKvMJ. Method of concept analyses and an extensive online literature have been used for this study. Overall data provided evidence that anxiety about death is rife within western culture. Its prevalence, particularly with women and significant number of cases elderly people experience less death anxiety than young people.