Dr. Will Cole, leading functional-medicine expert, consults people around the world via webcam at www.drwillcole.com and locally in Pittsburgh. He specializes in clinically investigating underlying factors of chronic disease and customizing health programs for thyroid issues, autoimmune conditions, hormonal dysfunctions, digestive disorders, and brain problems.Dr. Cole was named one of the top 50 functional-medicine and integrative doctors in the nation and is the author of Ketotarian in which he melds the powerful benefits of the ketogenic and plant-based diets.


“Cannatonic” is one known popular CBD-rich strain which is known to contain 6.5% CBD by weight, and the same amount of THC, making for one of the most medicinal strains out there. Sour Tsunami, Ghost Rider, Harlequin, Jamaican Lion and Omrita Rx3 have been tested several times by several labs as high as 18% CBD with equal or lower percentages of THC (3:2 ratio of CBD to THC in most cases).


Based on client feedback, as well as our own R&D, we have chosen to use Grape Seed Oil, which has a very high content of polyunsaturated fats, and is rich in Omega 3-6 as well as Omega-9 essential fatty acids. Grape Seed Oil is NOT recognized as an allergen by Health Canada (HC) or the Canadian Food Inspection Agency (CFIA); however, some people may have sensitivities to it.
I’ve experienced this myself on many occasions and I am not joking when I say that it can have detrimental effects on future public performances. In fact, I am confident that it can cause social anxiety afterward. In moments like these, CBD could be a lifesaver, as it can relieve the symptoms of Generalized Anxiety Disorder (GAD) and of specific phobias, one of which is the fear of speaking in front of people.
This cannabinoid is known as cannabidiol (CBD) and is the second most abundant cannabinoid found in cannabis on the market today. Research performed by G.W. Pharmaceuticals suggests that CBD could be used for treating symptoms of rheumatoid arthritis and other autoimmune diseases, diabetes, nausea, bowel disorders, and many other hard-to-control side effects. According to an research by Project CBD, CBD has even demonstrated neuroprotective effects, and its anti-cancer potential is currently being explored.

Pros: This item is organic and produced in the USA. The appearance of the oil is very much like extra virgin olive oil, as it should be. It has a green shade indicating that it is full spectrum and unrefined. Nature’s Blueprint also added natural peppermint to make it more palatable. I think it tastes fine straight from the dropper, but it can also be added to a smoothie of some sort or maybe hot tea? I appreciate that it has a clear label for the supplement facts and dosing. If you ever buy something that doesn’t, I certainly wouldn’t take it.
As you might know, both phobias and PTSD are marked by fear-related memories. According to a report published in 2017—titled, “Cannabidiol regulation of emotion and emotional memory processing: relevance for treating anxiety-related and substance abuse disorders”—by the British Pharmacological Society, several studies have confirmed that CBD reduces learned fear response in ways that could be helpful for patients suffering from phobias and PTSD. One study—titled, “Cannabidiol Regulation of Learned Fear: Implications for Treating Anxiety-Related Disorders”—in particular, details how CBD relieves fear response. The researchers found that it helps in three ways:
A. The Agriculture Improvement Act of 2018 changes certain federal authorities relating to the production and marketing of hemp, defined as cannabis (Cannabis sativa L.), and derivatives of cannabis with extremely low (less than 0.3 percent on a dry weight basis) concentrations of the psychoactive compound delta-9-tetrahydrocannabinol (THC). These changes include removing hemp from the Controlled Substances Act, which means that it will no longer be an illegal substance under federal law. However, Congress explicitly preserved the agency's current authority to regulate products containing cannabis or cannabis-derived compounds under the FD&C Act and section 351 of the Public Health Service Act. Please see the FDA’s statement on the signing of the Agriculture Improvement Act of 2018.

Success stories like Oliver’s are everywhere, but there’s not a lot of data to back up those results. That’s because CBD comes from cannabis and, like nearly all other parts of the plant, is categorized by the Drug Enforcement Agency (DEA) as a Schedule 1 drug—the most restrictive classification. (Others on that list: heroin, Ecstasy, and peyote.) This classification, which cannabis advocates have tried for years to change, keeps cannabis-derived products, including CBD, from being properly studied in the U.S.

When used in combination with delta-9-tetrahydrocannabinol as the product Sativex, cannabidiol was given a standard marketing authorization (ie. a Notice of Compliance (NOC)) by Health Canada for the following indications: 1) as adjunctive treatment for symptomatic relief of spasticity in adult patients with multiple sclerosis (MS) who have not responded adequately to other therapy and who demonstrate meaningful improvement during an initial trial of therapy [15];
And the products on the shelf aren't all the same, Ward said. "There can be many, many different varieties, and if you're thinking about doing this for medical reasons, you want to find a trusted source and do your research," she said. "Where does that oil come from, and how confident can you be that you know the exact percentages of the different cannabinoids in the product?"
Hemp oil is also rich in "super" polyunsaturated fatty acids, most notably gamma-linolenic acid and stearidonic acid. Although these are not essential fatty acids, they may help reduce the symptoms of atopic dermatitis and other skin conditions. However, the amount of these non-essential fatty acids varies according to the quality of the hemp plant the acids were derived from.

Despite this, it's important to know that inflammation is not inherently bad; in fact, it's a brilliant aspect of our immune system. When balanced, inflammation heals wounds and fights off infections. The problem with inflammation arises when it increases and never calms down. Like a forest fire burning on in perpetuity, people get hurt. Same goes with the fiery squall of insidious, chronic inflammation. As a natural anti-inflammatory, CBD can help quell the flame and fight chronic inflammation.
CBD may offer an option for treating different types of chronic pain. A study from the European Journal of Pain showed, using an animal model, CBD applied on the skin could help lower pain and inflammation due to arthritis. Another study demonstrated the mechanism by which CBD inhibits inflammatory and neuropathic pain, two of the most difficult types of chronic pain to treat. More study in humans is needed in this area to substantiate the claims of CBD proponents about pain control.
A. The agency has received reports of adverse events in patients using marijuana to treat medical conditions. The FDA is currently reviewing those reports and will continue to monitor adverse event reports for any safety signals attributable to marijuana and marijuana products, with a focus on serious adverse effects associated with the use of marijuana.
Can CBD oil help anxiety? Cannabidiol (CBD) is a chemical occurring in cannabis plants. It is possible to add CBD oil to food, and an increasing amount of evidence suggests that it may improve mental health, particularly anxiety. It does not seem to have adverse side effects, but CBD oil is illegal in some states. Learn more about CBD oil here. Read now
Most CBD oils are available in round-number concentrations such as 250mg, 500mg, and 1,000mg. While these strengths accommodate many CBD users, they may not be sufficient for those with preferences that fall outside round numbers. NuLeaf Naturals offers a less conventional selection of concentrations: 240mg, 725mg, 1,450mg, 2,425mg, and 4,850mg. This range ensures that most users will find a strength that works for them.

Although the exact mechanism and magnitude of effects of THC and CBD are not fully understood, CBD has been shown to have analgesic, anticonvulsant, muscle relaxant, anxiolytic, neuroprotective, anti-oxidant, and anti-psychotic activity. This wide variety of effects is likely due to it's complex pharmacological mechanisms. In addition to binding to CB1 and CB2 receptors of the endocannabinoid system, there is evidence that CBD activates 5-HT1A serotonergic and TRPV1–2 vanilloid receptors, antagonizes alpha-1 adrenergic and µ-opioid receptors, inhibits synaptosomal uptake of noradrenaline, dopamine, serotonin and gaminobutyric acid and cellular uptake of anandamide, acts on mitochondria Ca2 stores, blocks low-voltage-activated (T-type) Ca2 channels, stimulates activity of the inhibitory glycine-receptor, and inhibits activity of fatty amide hydrolase (FAAH) [1, 2].
It’s thought that CBD might affect your health by attaching to receptors in the body’s endocannabinoid system—a complex biological system involved in maintaining certain aspects of your health. Emerging research shows that endocannabinoids may play a role in regulating such functions as memory, sleep, and mood, as well as metabolic processes like energy balance.
Hemp oil is an abundant source of alpha-linolenic acid. Alpha-linolenic acid is an omega-3 fatty acid that is essential to proper organ function. It is similar to the omega-3 fatty acids found in fish oil, and can help prevent heart disease, arthritis and depression, according to the University of Maryland Medical Center. It can also help reduce low density lipoprotein cholesterol, the "bad" cholesterol that clogs arteries.
Cannabidiol did not reduce responses to negative emotional stimuli or reduce anxiety in healthy participants, according to a study published in Cannabis and Cannabinoid Research in 2017. Researchers tested participants' responses to negative images or words and threatening emotional faces and sensitivity to social rejection after taking oral cannabidiol.

A CNN program that featured Charlotte's Web cannabis in 2013 brought increased attention to the use of CBD in the treatment of seizure disorders.[67][68] Since then, 16 states have passed laws to allow the use of CBD products with a doctor's recommendation (instead of a prescription) for treatment of certain medical conditions.[69] This is in addition to the 30 states that have passed comprehensive medical cannabis laws, which allow for the use of cannabis products with no restrictions on THC content.[69] Of these 30 states, eight have legalized the use and sale of cannabis products without requirement for a doctor's recommendation.[69]


One of the most profound uses of cannabidiol oil is for the relief of arthritic pain. There are two kinds of arthritis, rheumatoid and osteoarthritis, both resulting in swelling and stiffness in joints.  Scientific studies have documented that the application of CBD oil can help assuage the pain caused by inflammations. Results have been encouraging. Health associations and the government, alike, are optimistic about the role of CBD oil in bringing solace to arthritic patients.
Nature’s Script offers a wide range of CBD oil products. Tinctures are available in 30mL containers and 300mg, 600mg, 1000mg, 2,000mg, and 4,000mg concentrations. These products come in watermelon or peppermint flavors. Nature’s Script recommends a beginning dose of 5mg to 10mg per day, and to gradually increase the dose until the desired effects are reached. Nature’s Script also sells CBD capsules and vape juice, as well as gummies and mixing syrup for those who enjoy edibles and a pain-relief topical sold in one- and four-ounce containers. These products do not contain any THC and pose no risk for drug test takers.
A. When a product is in violation of the FD&C Act, FDA considers many factors in deciding whether or not to initiate an enforcement action. Those factors include, among other things, agency resources and the threat to the public health. FDA also may consult with its federal and state partners in making decisions about whether to initiate a federal enforcement action.

The ACMPR requires that all Licensed Producers display total levels of potential THC and CBD on their product labels. Total potential THC is the total amount of THC available when all THCa (tetrahydrocannabinolic acid) is decarboxylated. Total potential CBD is the total of CBD available when all the CBDa (Cannabidiolic acid) is decarboxylated. Learn more about decarboxylation here.
The case study notes that advanced chemotherapeutic agents had failed to control the blast counts (cells in the blood and bone marrow) in the patient and had devastating side effects that ultimately resulted in death. The cannabinoid therapy, on the other hand, had no toxic side effects and only psychosomatic properties, with an increase in the patient’s vitality.
Industrial hemp contains, by weight, far less CBD than CBD-rich cultivars such as Harlequin or Sour Tsunami. This means that producing a single 10 mL dose of CBD would require the cultivation and extraction of far more hemp than it would from whole-plant marijuana; thus raising the risk of exposing users to more contaminants. Hemp is classified as a “bioaccumulator,” or a plant that naturally absorbs toxicants from the soil.
One of the earliest success stories involves a young girl named Charlotte who was given an ingestible oil derived from Charlotte’s Web, a CBD strain that was specifically developed to provide her with all the benefits of the drug without the high. In less than two years, Charlotte went from a monthly seizure count of 1,200 to about three. Other success stories followed and more parents have begun to speak out, particularly parents who are desperate for access to this life-saving treatment.
Some medications are changed and broken down by the liver. Cannabidiol might decrease how quickly the liver breaks down some medications. In theory, using cannabidiol along with some medications that are broken down by the liver might increase the effects and side effects of some medications. Before using cannabidiol, talk to your healthcare provider if you take any medications that are changed by the liver.
Reality: Hemp oil is an increasingly popular product, used for an expanding variety of purposes. The washed hemp seed contains no THC at all. The tiny amounts of THC contained in industrial hemp are in the glands of the plant itself. Sometimes, in the manufacturing process, some THC- and CBD-containing resin sticks to the seed, resulting in traces of THC in the oil that is produced. The concentration of these cannabinoids in the oil is infinitesimal. No one can get high from using hemp oil.
Full Spectrum CBD Oil is commonly used for assisting with pain, stress, sleep, anxiety, and more. To assist with Pain, Stress, Anxiety take as recommended once a day in the morning. To assist with sleep take as recommended in the evening. All of Zatural's Hemp products are always 0 THC. If needed, one may increase the daily recommended dosage slowly according to their needs. 

The active ingredients in cannabis may be extracted and separated in a number of ways, including water, CO2, alcohol, and organic solvents, such as butane. At Canna Farms, we like to keep things simple! We use a proprietary solvent-less extraction process to obtain a pure, natural, concentrated whole-plant cannabis resin. This resin is rich in THC, CBD, and other cannabinoids and terpenes. This process does NOT use any harsh or dangerous solvents, which ensures safety for our clients as well as our staff.
The fatty acids in hemp oil offer certain health benefits. For example, the oil contains sitosterol, which can help lower cholesterol. It also contains tocopherols, which have antioxidant properties to help prevent your cells from damage, and anticancer agents, according to the "Journal of Nutraceuticals, Functional and Medicinal Foods." Hemp oil also contains a 3-to-1 ratio of omega-3 fatty acids to omega-6 fatty acids, which can help lower your risk of cancer, inflammation and blood clots, the "Journal of Nutraceuticals, Functional and Medicinal Foods" reports. Fatty acids also promote normal brain function.
Research suggests that CBD may exert some of its pharmacological action through its inhibition of fatty acid amide hydrolase (FAAH), which may in turn increase the levels of endocannabinoids, such as anandamide, produced by the body.[7] It has also been speculated that some of the metabolites of CBD have pharmacological effects that contribute to the biological activity of CBD.[40]
Based on client feedback, as well as our own R&D, we have chosen to use Grape Seed Oil, which has a very high content of polyunsaturated fats, and is rich in Omega 3-6 as well as Omega-9 essential fatty acids. Grape Seed Oil is NOT recognized as an allergen by Health Canada (HC) or the Canadian Food Inspection Agency (CFIA); however, some people may have sensitivities to it.

Cannabis has been around for thousands of years and is believed to have originated in South or Central Asia. The two main species of cannabis are Cannabis sativa and Cannabis indica. Both Cannabis sativa and indica contain varying amounts of psychoactive and nonpsychoactive components. Cannabis sativa is more commonly known for its stimulatory, mental effects while Cannabis indica is more known for its relaxing, body-calming effects.
Reflecting the next morning, I was most surprised by the fact that I never felt "high" in any way—there was never a moment of It's kicking in; I can feel it now like with pain medications or even anti-anxiety drugs. Considering it takes time, consistency, and the right dosage to experience the full effect, I continued taking the oil once a day for the next six days. Here's what went down.

Well, apart from day to day anxiety that most of us suffer with, anxiety is actually a very complex disorder, which can be at times extremely paralyzing and debilitating. According to recent data published by the National Institute of Mental Health, Anxiety disorders affect 19.1% of adults in the United States in any given year. Furthermore, it is estimate that 31.1% of American adults experience any anxiety disorder at some time in their lives.
Another common side effect that hemp oil can cause in supplement users involves the cardiac system and bloodstream. As the PeaceHealth website states, hemp oil products can directly affect the anticoagulant properties of platelets within the blood, often inhibiting their very production. As a result, patients who are currently being treated for a blood clotting deficiency or other cardiac medical condition are strongly advised to stay away from hemp oil supplements of any kind due to possible symptom complications.
When I came across the Nutiva Organic Hemp Oil it was so much less I started checking to find out what the difference was. I read the reviews and everyone was saying how much it helped. I decided to try it, not believing it was possible I might get some relief, but for the price what was there to lose, except pain. Well it's been six days since it arrived. I took one tablespoon that evening. Man, like drinking nutty oil, so I grabbed a piece of bread to get the taste out of my mouth. By morning I was feeling so much better. By that evening I noticed I didn't need a pain pill to help. By the third day I was able to sit up in bed without holding on to something. Today, the sixth day the pain in my legs, knees and hip joints is gone, but the clincher was the horrible pain in my lower back is almost gone. Swelling in my right hip is gone unless I get to active, then it becomes a dull ache. Best of all, I can sleep. I've been immobilized for several years, unable to do much for very long because I always had to sit back down. I was walking pitched forward to get around. Now I have to remember to straighten up. I not only look but I feel younger than my 72 years. No more pain pills for me. I'm so gitty over this I can't stop talking about it to my family and friends.
Cannabidiol (CBD) is a naturally-occurring constituent of industrial hemp (cannabis sativa) plants. It is the most abundant non-psychoactive cannabinoid found in cannabis and is being scientifically investigated for numerous reasons. Most people have heard of a cannabinoid called THC, which is the ingredient in cannabis that gets users high. Unlike THC, CBD (cannabidiol) is a non-psychoactive cannabinoid and does not cause a high.
According to the case report, it was charted by the girl’s oncologist that the patient “suffers from terminal malignant disease. She has been treated to the limits of available therapy … no further active intervention will be undertaken.” She was then placed in a palliative home care and told to prepare for her disease to overwhelm her body. She was expected to suffer a stroke within the next two months.
It was actually a bad bout of jet lag after a trip to California that inspired me to finally test out the CBD oil (I'll admit that my weed-based reservations kept me from trying it for the first few months). Knowing that the oil had also helped people with sleep issues, I squeezed one full dropper of the Everyday Plus oil onto my tongue, per the instructions, and waited.
Unrefined hemp oil does not have a very long shelf life. The oil quickly goes rancid, unless it is stored in dark containers in a refrigerated environment. People who use unrefined hemp oil generally purchase it in small amounts so that it will not become rancid. The oil is also not suitable for cooking, because it has a very low smoking point. Refined hemp oil is much more shelf stable, although many of the benefits of it are not present after refining.
By 1942, cannabis was removed from the U.S. Pharmacopoeia because of persistent concerns about its potential to cause harm. In 1951, Congress passed the Boggs Act, which included cannabis with narcotic drugs for the first time. In 1970, with the passage of the Controlled Substances Act, cannabis was classified as a Schedule I drug, giving it no accepted medicinal use.
Product freshness is highly dependant on storage conditions such as temperature, and exposure to oxygen and light. To prevent degradation of the cannabinoids over time (and to prevent the carrier oil itself from becoming rancid), Cannabis Oils should be stored in a cool, dark, and dry place (a fridge or freezer is perfect for this purpose). Depending on the carrier oil used, the cannabis oil may become slightly solid or cloudy. To regain its clarity and consistency, simply place the bottle in a glass of warm water and allow the contents of the bottle to warm.
James Joliat, a 35-year-old video producer in Denver, has long experienced muscle and joint pain—mostly related to sports injuries. He says he started looking at natural remedies as an alternative to the prescription patches and pills his doctor recommended. After experimenting with homemade rubs infused with plant compounds—stuff like arnica and turmeric—he eventually stumbled onto topical cannabidiol (CBD) rubs.
A phytocannabinoid derived from Cannabis species, which is devoid of psychoactive activity, with analgesic, anti-inflammatory, antineoplastic and chemopreventive activities. Upon administration, cannabidiol (CBD) exerts its anti-proliferative, anti-angiogenic and pro-apoptotic activity through various mechanisms, which likely do not involve signaling by cannabinoid receptor 1 (CB1), CB2, or vanilloid receptor 1. CBD stimulates endoplasmic reticulum (ER) stress and inhibits AKT/mTOR signaling, thereby activating autophagy and promoting apoptosis. In addition, CBD enhances the generation of reactive oxygen species (ROS), which further enhances apoptosis. This agent also upregulates the expression of intercellular adhesion molecule 1 (ICAM-1) and tissue inhibitor of matrix metalloproteinases-1 (TIMP1) and decreases the expression of inhibitor of DNA binding 1 (ID-1). This inhibits cancer cell invasiveness and metastasis. CBD may also activate the transient receptor potential vanilloid type 2 (TRPV2), which may increase the uptake of various cytotoxic agents in cancer cells. The analgesic effect of CBD is mediated through the binding of this agent to and activation of CB1. Check for active clinical trials using this agent. (NCI Thesaurus)

CBD has proven neuroprotective effects and its anti-cancer properties are being investigated at several academic research centers in the United States and elsewhere. A 2010 brain cancer study by California scientists found that CBD “enhances the inhibitory effects of THC on human glioblastoma cell proliferation and survival.” This means that CBD makes THC even more potent as an anticancer substance. Also in 2010, German researchers reported that CBD stimulates neurogenesis, the growth of new brain cells, in adult mammals.


Hemp Oil is processed from the seeds and stalks of the hemp plant and despite its source, it contains little to none of the psychoactive element Tetrahydrocannabinol (THC), meaning it cannot get you ‘high’. For instance hemp may contain 0.3-1.5% of THC whilst marijuana contains anything from 5% to 20% plus. Hemp oils main components are in fact omega fatty acids, similar to those which can be found in fish and olive oil.

CBD oil alleviates physical pain and anxiety – both of which can have a negative impact on sleep. Additionally, CBD oil can actually prolong sleep for some, leading to more rest from night to night. Most medical experts agree that marijuana is not particularly beneficial for individuals with medical conditions and/or mental health disorders, as the THC can increase their symptoms; this makes CBD oil a good alternative option for people with the following sleep disorders and medical conditions.

Anxiety disorders are the most common mental health concern in the United States. An estimated 30 percent of adults in the United States (that's 66 million people) and an estimated 25 percent of teenagers and preteens are affected by anxiety. As a functional medicine practitioner, I see many people who struggle with anxiety and panic attacks, and from these statistics, it should be no surprise. But just because something is common doesn't make it normal. Fortunately, new insights into the cause of anxiety may help with the development of more effective treatment options.

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