“THC”—the more-famous, high-inducing compound in cannabis—“works directly on the cannabinoid system, meaning it attaches to receptors and mimics some of our own internal endocannabinoids,” says Igor Grant, a professor and chair of psychiatry at the University of California, San Diego School of Medicine. But CBD’s interaction with the endocannabinoid system is subtler. “Normally, these endocannabinoid-signaling molecules are broken down by enzymes, and one thing CBD does is interfere with the actions of those enzymes.”
A CNN program that featured Charlotte's Web cannabis in 2013 brought increased attention to the use of CBD in the treatment of seizure disorders.[67][68] Since then, 16 states have passed laws to allow the use of CBD products with a doctor's recommendation (instead of a prescription) for treatment of certain medical conditions.[69] This is in addition to the 30 states that have passed comprehensive medical cannabis laws, which allow for the use of cannabis products with no restrictions on THC content.[69] Of these 30 states, eight have legalized the use and sale of cannabis products without requirement for a doctor's recommendation.[69]

CBD and THC interact with our bodies in a variety of ways. One of the main ways they impact us is by mimicking and augmenting the effects of the compounds in our bodies called “endogenous cannabinoids” - so named because of their similarity to the compounds found in the cannabis plant. These “endocannabinoids” are part of a regulatory system called the “endocannabinoid system”.
It is important to note that the federal government still considers cannabis a dangerous drug and that the illegal distribution and sale of marijuana is a serious crime. Under the Controlled Substances Act (CSA), marijuana is still considered a Schedule 1 drug. Cultivation and distribution of marijuana are felonies; possession for personal use is a misdemeanor; possession of “paraphernalia” is also illegal. Cultivating 100 plants or more carries a mandatory minimum sentence of five years according to federal statutes.
UPDATE! I ordered this product again because the first bottle worked magnificently however upon receiving the new bottle, I live in Florida and noticed that the bottle was overwhelmingly warm when received... so I put it in the refrigerator and waited for my other bottle to finish to open this one. I have now ingested this on two separate occasions and have become violently ill upon consumption. This product is not consistent, be extremely cautious when buying and using this product definitely test it to make sure it's not rancid before you add it to your meals. I am extremely upset about this and wish the company would contact me..

I was feeling anxious throughout the day, and it was the first time I wasn't sure if the CBD oil helped or not. I didn't leave the house like I intended (one of my old anxiety-driven habits), which wasn't good. However, I did feel like I wasn't fixating as much on how anxious I felt (yes, I get anxious about feeling anxious). But I still felt like sh*t.
About 49% of the weight of hempseed is an edible oil[7] that contains 76% as essential fatty acids; i.e., linoleic acid, omega-6 (LA, 54%), alpha-linolenic acid, omega-3 (ALA, 17%), in addition to gamma-linolenic acid (GLA, 3%), monounsaturated fat (5% to 11%), and stearidonic acid (2%).[8] Hemp seed oil contains 5% to 7% saturated fat.[7][8] In common with other oils, hempseed oil provides 9 kcal/g. Compared with other culinary oils it is low in saturated fatty acids.[8]

Over the past few decades, most strains have been bred to increase the amount of the main psychoactive component, (-)-trans-delta9-tetrahydrocannabinol (THC). However, within the past decade, researchers have become increasingly interested in the medical benefits of another compound found in both plants, known as cannabidiol (CBD). CBD is a non-psychoactive component of the cannabis plant but is reputed to help with a myriad of medical conditions.
If medical marijuana is illegal in a given state, THC levels determine whether a CBD product is illicit or not. In most places, the limit is extremely low. We’re talking under 1 percent THC, with some states opting for a cap as low as 0.3 percent. In this case, the only source that would work is hemp, and CBD products will, therefore, be hemp-derived.

Marijuana oil is created by extracting the THC compound (and other cannabinoids) from marijuana (the high-THC version of cannabis). It is used medically and recreationally for its high THC content. This oil is highly regulated in the US and across the world. Marijuana oil is not federally legal, but it may be used in states allowing for the recreational and medicinal use of marijuana oil. The latter requires a doctor’s prescription.

Serotonin: Most people associate serotonin with happiness. However, the role of this neurotransmitter is very complex, and its effects depend on where it is and what it binds to. (Contrary to popular belief, more serotonin is not necessarily better — dysfunction can stem from low or high levels of serotonin, as well as from malfunctions with their receptors.) Serotonin has at least 14 different receptors, but CBD specifically binds to 5-HT1A which is thought to have the strongest role in anxiety disorders. The anti-anxiety drug buspirone also binds to this particular receptor, which explains the anti-anxiety effects of CBD on rats exposed to stressful situations.


@lalyfa In 2010 I went off a cocktail of psychotropics including antidepressants, antianxiety and antipsychotics cold turkey. The meds were wrong for me and the withdrawal was severe and I rarely slept, had RLS, neuropathy and cranky beyond words. Some of these meds took 9+ months to clear my system. Be sure to follow doctor's advice. I did not have a doctor at the time and would not go to the ER knowing it would have resulted in more abuse. Not an intelligent thing to do and not sorry I made the choice even though the experience was horrific and would not reccomend anyone go this route. As to how long the withdrawal lasts the best thing is to discuss this with a pharmacist as this is where their training is and they understand much better and be of help. Wishing you the best.
CBD and THC interact with our bodies in a variety of ways. One of the main ways they impact us is by mimicking and augmenting the effects of the compounds in our bodies called “endogenous cannabinoids” - so named because of their similarity to the compounds found in the cannabis plant. These “endocannabinoids” are part of a regulatory system called the “endocannabinoid system”.
Weight plays a role in the effects of CBD oil, and bottle size should be selected based on how much you weigh. Let’s say you weigh less than 130 pounds and desire light CBD oil effects; this means that 11 mg or less will probably suffice per dose, giving roughly 40 doses from a 450-mg concentration. If you weigh more than 230 pounds and desire strong effects, then this same concentration will supply roughly 10 doses. 

These mounting developments in the elicited a problem amongst cannabis cultivators across the US: decades of selectively breeding cannabis to achieve the maximum amount of THC for a strong high reduced the overall preponderance of CBD in cultivars across the country to trace lows. Essentially, CBD had been selectively bred out of existence across the country.


Cannabidiol can cause sleepiness or drowsiness. Using it along with other herbs and supplements that have the same effect might cause too much sleepiness. Some of these herbs and supplements include calamus, California poppy, catnip, hops, Jamaican dogwood, kava, L-tryptophan, melatonin, sage, SAMe, St. John's wort, sassafras, skullcap, and others.
Cannabis sales have been illegal since the 1970 Controlled Substances Act was passed, with the only exceptions being the products made from the "mature stalk" and "sterilized seed" of the hemp plant, which could still be sold since they contained little to no psychoactive components. Even today, federal law has not changed its stance on cannabis. On the state level, however, things have changed dramatically. As of this writing, there are 30 states that have legalized the sale of cannabis in some form, whether that be medicinally or recreationally. Because federal law continues to outlaw the production and sales of cannabis aside from the CBD oil and hemp seed oil from hemp plants, it is illegal for states that have legalized cannabis to sell products across state borders.
Tetrahydrocannabinol (THC) is the naturally occurring compound that famously produces cannabis’ mind-altering states. The CBD compound found in the plant, however, does not have psychoactive properties. CBD produces a calming effect on the mind, making it a good treatment for people with social anxiety and other nervous disorders. When combined with THC in stronger amounts, CBD can help balance out the medication, ensuring that the user does not get too high. Oil can be slightly harder to procure and more expensive than medical marijuana flowers, depending on state laws. Smoking cannabis can be more beneficial to some people, largely depending on their condition.
When medical marijuana became a thing in Seattle, before full legalization, many of my friends found relief from their darker moods with cannabis. At that time, I didn’t have a MMJ card to buy the medical stuff, but a buddy gave me some CBD oil he wasn’t using and I took it in the winter. The grey Seattle rain wasn’t getting to me anymore. I would smile a lot more and it helped me get through a serious break-up and transition in my life. I remember at the time hearing cases like this: http://seattle.cbslocal.com/2014/02/05/study-suicide-rates-fell-in-states-where-medical-marijuana-is-legal/ . How suicide rates dropped in states where medical and recreational use became legal.
Cannabidiol is currently a class B1 controlled drug in New Zealand under the Misuse of Drugs Act. It is also a prescription medicine under the Medicines Act. In 2017 the rules were changed so that anyone wanting to use it could go to the Health Ministry for approval. Prior to this, the only way to obtain a prescription was to seek the personal approval of the Minister of Health.
Omegas 3 and 9 fatty acids act as an anti-inflammatory and help quell irritating skin conditions while helping your skin heal itself. Omega 6 is essential at maintaining the overall health of your skin's natural barrier so it can better maintain moisture and ward off pesky acne-causing bacteria. High in skin-loving antioxidants, Hemp Seed Oil helps protect against sun damage and diminish signs of aging. 
A study done in 2010—titled, Cannabidiol Reduces the Anxiety Induced by Simulated Public Speaking in Treatment-Naïve Social Phobia Patients—explored this issue in more detail. They took two groups—one was given a placebo and the other was given a single dose (600 mg) of CBD oil. About 1.5 hours later, they put both groups through a public speaking simulation and found that: “Pre-treatment with CBD significantly reduced anxiety, cognitive impairment and discomfort in their speech performance, and significantly decreased alert in their anticipatory speech.”
CBD oil may be of some benefit to those with addiction, suggests a review published in the journal Substance Abuse in 2015. In their analysis of 14 previously published studies, scientists determined that CBD may have therapeutic effects in people with opioid, cocaine, and/or psychostimulant addiction. They also found that CBD may be beneficial in the treatment of cannabis and tobacco addiction. There is some evidence that CBD may block or reduce the effects of THC on the mind.
‘There is intriguing preclinical and some clinical data supporting the use of cannabidiol (CBD) as an effective treatment for the management of anxiety disorders,’ says Dr Ware. ‘There are more than 30 preclinical studies that investigate the anxiolytic [anxiety-reducing] properties of CBD. These studies generally support the position that CBD has an effect on reducing anxiety behaviour.’

Some users speculate about appropriate dosages or methods of application—including whether or not a small amount of THC boosts CBD’s effects, or whether different methods of administration lead to quicker or more significant effects. Some CBD producers also claim that it has a cumulative effect, and so needs to be used regularly to produce a benefit. But Grant says it’s tough to say at this point exactly how people should (or shouldn’t) be using CBD.
I've tried almost everything to treat my anxiety, which I've struggled with for years, with varying degrees of success. Weightlifting? Helped more than I thought. Legal marijuana? Truly a game-changer. However, given the fact that I live in a state where marijuana is not yet legal, I'm still searching for ways to live a relatively normal life with the tools I have available to me. Yay!
Some CBD oil brands can be evasive when it comes to product testing details. Populum addresses this by including a hard copy of the oil’s lab testing results in the product packaging. Full lab results are easily accessible on the brand’s website, as well. Prices for the Populum CBD oil range from 18 to 24 cents per milligram, depending on the container size, making it a relatively inexpensive full spectrum product. All U.S. military veterans receive a 25% discount, as well. Populum offers a risk-free 30-night product trial.
In addition to the well-known activity on CB1 and CB2 receptors, there is further evidence that CBD also activates 5-HT1A/2A/3A serotonergic and TRPV1–2 vanilloid receptors, antagonizes alpha-1 adrenergic and µ-opioid receptors, inhibits synaptosomal uptake of noradrenaline, dopamine, serotonin and gamma-aminobutyric acid (GABA), and cellular uptake of anandamide, acts on mitochondria Ca2+ stores, blocks low-voltage-activated (T-type) Ca2+ channels, stimulates activity of the inhibitory glycine-receptor, and inhibits activity of fatty amide hydrolase (FAAH) [1, 2].
CBD might not be as potent as some of these antidepressants, but it targets the problem in a much more holistic manner. Instead of blunting your emotions or inhibiting your ability to feel depressed by overloading your brain with neurotransmitters, CBD helps you overcome acute symptoms of depression so you’re actually able to identify and heal the root of the problem.
Unfortunately due to the disappointing and down right inaccurate position of the federal government in classifying Cannabis as a schedule one drug, most research institutions risk federal funding if they conduct real research on Cannabis. This has dramatically limited the potential for real research by real scientists to be conducted. That research is critical to better understanding the multitude of therapeutic effects of the various chemical constituents found in Cannabis.

@gailb I am in SC where it can only be prescribed for last days of cancer pain because they don't care if they get "addicted". I will not get on my soapbox, but I would much prefer being addicted to marijuana as there have never been any scientific studies that prove a physical addiction to marijuana as opposed to opiates. Maybe a psychological dependence, but two very different animals. However, I do believe the CBD oil that does not contain THC is legal federally and in all states.
But remember, it is very difficult, if not impossible, to obtain a pure CBD extract or oil from the cannabis plant. Anyone who buys a CBD oil, extract, or other CBD product should assume that it is a mixture of CBD and other cannabinoids. All other cannabinoids, including THC and the other 118 identified cannabinoids in the cannabis plant, as well as all synthetic cannabinoids, are prohibited in-competition.
CBD may offer an option for treating different types of chronic pain. A study from the European Journal of Pain showed, using an animal model, CBD applied on the skin could help lower pain and inflammation due to arthritis. Another study demonstrated the mechanism by which CBD inhibits inflammatory and neuropathic pain, two of the most difficult types of chronic pain to treat. More study in humans is needed in this area to substantiate the claims of CBD proponents about pain control.

Our pick for Best Customer Experience is Populum, an Arizona-based CBD brand that offers complete product transparency and great deals for shoppers. Populum offers a full spectrum CBD oil in 250mg, 500mg, and 1000mg concentrations. The product is made with cold-pressed orange oil for a light citrus taste, as well as grapeseed and coconut oils for added flavors. Populum also offers a cooling topical salve that relaxes aching joints and muscles, as well as a pet oil for dogs and cats. Additionally, the CBD oil, topical salve, and pet oil are packaged in an inexpensive ‘Starter Kit’ designed for first-time users.
Hemp oil is also rich in "super" polyunsaturated fatty acids, most notably gamma-linolenic acid and stearidonic acid. Although these are not essential fatty acids, they may help reduce the symptoms of atopic dermatitis and other skin conditions. However, the amount of these non-essential fatty acids varies according to the quality of the hemp plant the acids were derived from. 

Our Editor’s Pick is the tincture from CBDistillery. This tincture is available in five strengths ranging from 250mg to 5,000mg, which accommodates a wide range of THC preferences, as well as 15 and 30 milliliter containers. The tincture has a price-point that is slightly below average, making it a good option for value seekers. The tincture, which is non-flavored, routinely undergoes third-party testing to ensure safety and high quality; the testing results are available on CBDistillery’s product pages.
In making the two previous determinations about THC, why did FDA conclude that THC is an active ingredient in a drug product that has been approved under section 505 of the FD&C Act? In making the two previous determinations about CBD, why did FDA determine that substantial clinical investigations have been authorized for and/or instituted, and that the existence of such investigations has been made public?
NIDA is currently collaborating with the National Institute on Neurological Disorders and Stroke to evaluate CBD in animal models of epilepsy in order to understand the underlying mechanisms and optimize the conditions under which CBD may treat seizure disorders, and determine whether it works synergistically with other anti-seizure medications. In addition, clinical trials are currently underway by GW Pharmaceuticals, testing the efficacy of Epidiolex, a purified CBD extract, for treatment of pediatric epilepsy.
Although hemp and marijuana are essentially different cultivars of the same plant – Cannabis sativa L – marijuana has been cultivated to concentrate high levels of THC (frequently as much as 18%), in the plant’s flowering tops, whereas hemp, which is primarily grown in Europe to make clothing, paper, biofuels, bioplastics, nutritional supplements, cosmetics, and foods, contains less than 0.3% THC.
“THC”—the more-famous, high-inducing compound in cannabis—“works directly on the cannabinoid system, meaning it attaches to receptors and mimics some of our own internal endocannabinoids,” says Igor Grant, a professor and chair of psychiatry at the University of California, San Diego School of Medicine. But CBD’s interaction with the endocannabinoid system is subtler. “Normally, these endocannabinoid-signaling molecules are broken down by enzymes, and one thing CBD does is interfere with the actions of those enzymes.”
When people cite the so-called negative effects of cannabis, they are usually due to the presence of  tetrahydrocannabinol (THC), the compound that causes the psychoactive effects. Some of these, such as paranoia and increased levels of stress, may be negated by the balancing power of cannabidiol. The chemical can help increase feelings of calm and self-awareness to make it safer for patients to use cannabis for medical treatment without risking common side effects. Since each patient reacts differently to treatment, some may experience differing effects that can occur during cannabis consumption.
A. The FDA is aware that there are potential adverse health effects with use of marijuana in pregnant or lactating women. Published scientific literature reports potential adverse effects of marijuana use in pregnant women, including fetal growth restriction, low birth weight, preterm birth, small-for-gestational age, neonatal intensive care unit (NICU) admission, and stillbirth. [1, 2, 3] Based on published animal research, there are also concerns that use of marijuana during pregnancy may negatively impact fetal brain development.  [4, 5, 6 ] The American College of Obstetricians and Gynecologists (ACOG) recommends that women who are pregnant or contemplating pregnancy should be encouraged to discontinue marijuana use. In addition, ACOG notes that there are insufficient data to evaluate the effects of marijuana use on breastfed infants; therefore, marijuana use is discouraged when breastfeeding. [7] Pregnant and lactating women should talk with a health care provider about the potential adverse health effects of marijuana use.
CBD has powerful effects on the liver as well. Have you ever had a prescription that warns you not to take the medicine along with grapefruit? That’s because grapefruit inhibits certain drug-metabolizing enzymes in your liver, resulting in much higher levels of your medication in your bloodstream. CBD does the same thing, so it is wise to discuss your medication regimen with a doctor or pharmacist before engaging in CBD therapy.

Due to its high content of omega 3 and omega 6 fatty acids, hemp oil has a composition similar to skin lipids, which makes it an excellent natural emollient and moisturizer. It is especially useful for dry, tired or dehydrated skin and nails. It increases the skin elasticity and water retention capacity in tissues. Pure hemp oil can be used to treat dry hair and is often included in hair conditioners.
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